Battle of the Anti-Grey Titans: REGENSIFY Lotion vs Trichoderm Serum

Comparing REGENSIFY Hair Melanin Booster Lotion vs Trichoderm Anti-Grey Max Hair Serum

Grey hair reversal has become one of the most in-demand segments of haircare, with biotechnology-driven solutions offering real hope beyond simple hair dyes. Two products leading the way are REGENSIFY Hair Melanin Booster Lotion and Trichoderm Black Series Anti-Grey MAX Hair Serum. Both leverage advanced active ingredients designed to stimulate melanin regeneration and restore natural hair color, but they differ in formulation, scope, and supporting benefits. The Trichoderm brand is owned by Biohealth Plus Limited, a company based in Hong Kong.

Key Differences between REGENSIFY Hair Melanin Booster Lotion vs Trichoderm Anti-Grey Max Hair Serum

• For Trichoderm Anti-Grey Max Hair serum, it contains three patented actives - Greyverse, Silverfree and MelanoGray. 
• For REGENSIFY Hair Melanin Booster Lotion, instead of using Silverfree, we prefer to use Darkenyl so it has Greyverse, Darkenyl and MelanoGray.
• In addition, the REGENSIFY Hair Melanin Booster Lotion is powered with supporting actives such as Adenosine, Coenzyme Q10, SantEnergy, Biotin and He Shou Wu. The Trichoderm Anti-Grey Hair serum does not have any other supporting actives that are beneficial for anti-grey prevention, other than the three main actives (Greyverse, Silverfree and MelanoGray).
• Another difference is the Trichiderm Anti-Grey Max Hair serum is formulated to be a lightweight, water-and-alcohol-based serum while the REGENSIFY Hair Melanin Booster Lotion is formulated to be a lotion based with natural oils (Argan, Jojoba), making it more nourishing and scalp-friendly.

Greyverse vs Silverfree

While both Greyverse and Silverfree are both peptides of different formula for anti-greying, there are some differences between Greyverse and Silverfree.

Greyverse, created by Lucas Meyer Cosmetics, is a biomimetic peptide that can directly stimulates melanogenesis by boosting the expression of key pigmentation enzymes and reactivating melanocyte activity. Its strength lies in re-starting melanin production within hair follicles, targeting the root cause of greying. While Silverfree emphasizes protection + gradual restoration, Greyverse is more of an activator, directly prompting pigment production for visible reversal over time.

Silverfree, developed by Sederma, is a biomimetic lipopeptide designed to re-educate hair bulbs and restore natural pigmentation while defending against oxidative stress. It works by stimulating pigmentation genes (CREB, MITF, TYRP1) and strengthening the hair follicle’s redox balance, giving protection against both intrinsic and extrinsic oxidative damage. In essence, Silverfree not only encourages pigment recovery but also improves the overall resilience and quality of greying hair.

To summarise:

• Greyverse™

  • A patented biomimetic peptide based on Palmitoyl Tetrapeptide-20 by Lucas Meyer Cosmetics

  • Focuses on reducing oxidative stress and reactivating melanocyte stem cells.

  • Mechanism: “repair + restart” of pigment-producing capacity.

  • Clinical data: visible reversal of grey density with continued use.

• Silverfree™

  • A patented biomimetic peptide based on Palmitoyl Dipeptide-52 by Sederma

  • Marketed as protecting hair follicle proteins and delaying the appearance of greys rather than strongly reversing them.

  • Mechanism: antioxidant, stress-protection, helps maintain pigment longer.

  • Clinical data: more on prevention / slowing than reversal.

Greyverse vs Silverfree: How They Differ

If you had to choose one:
👉 Greyverse™ is the stronger pick if the positioning is anti-grey reversal.
👉 Silverfree™ may be considered if the positioning is maintenance and prevention in younger demographics.

So they overlap, but Greyverse is usually seen as the more impactful peptide if have to include only one. Hence, if REGENSIFY have to choose between Greyverse vs Silverfree, REGENSIFY will pick Greyverse.

Tyrosine-Based Actives = The Proven Backbone

Compared to newer mechanisms such as peptide activation (e.g Greyverse), tyrosine pathway boosting with actives like Darkenyl and MelanoGray remains the most established and clinically validated approach for reversing grey hair. This is because it leverages the natural melanin biosynthesis cascade that the body already uses.

• Tyrosine = the raw material for melanin.

• Tyrosinase = the enzyme that converts tyrosine into melanin.

By supplying and optimizing this pathway, tyrosine boosters deliver the most consistent results backed by clinical studies.

That’s why Darkenyl + MelanoGray are considered the “must-have duo” in any serious anti-grey formulation targeting the tyrosine pathway. 

Darkenyl alone or MelanoGray alone are not good enough. Both Darkenyl and MelanoGray are complementary and combining Darkenyl + MelanoGray together ensures greater effectiveness in the Tyrosine pathway approach. Hence, we decided to choose Darkenyl over Silverfree. You can read the previous blog titled Darkenyl + MelanoGray: Double Defense Against Grey Hairs.

Why Combine Them? — The Double Melanin Booster Effect

When paired together, Darkenyl + MelanoGray create a broader, complementary mechanism:

• More substrate for melanin production (both deliver Acetyl Tyrosine).

• Stronger enzymatic activation (Darkenyl’s zinc supports tyrosinase).

• Hydrogen peroxide detoxification (MelanoGray’s gluconolactone reduces oxidative shutdown).

• Wider antioxidant spectrum (Darkenyl: green tea & Larix | MelanoGray: tangerine & gluconolactone).

👉 Result: A more complete follicle environment for repigmentation, protection, and prevention of further greying.

Ingredient Formulation & Base

• Trichoderm Anti-Grey Max Hair serum: Lightweight, water-and-alcohol-based serum. Faster absorption, but alcohol content may be slightly drying for sensitive scalps. However, spraying serums at the back and sides of the head can be challenging — many users find it hard to target grey patches precisely. This can lead to inconsistent results, as the product may not reach where it’s most needed.

• REGENSIFY Hair Melanin Booster Lotion: Lotion-based with natural oils (Argan, Jojoba), making it more nourishing and scalp-friendly. Richer texture ideal for those with dry or thinning hair. Its lotion format is also easier to apply evenly to the back and sides of the head, giving it a practical advantage over serum formats. Lotion texture, slightly richer, requires massaging into scalp. With lotion, you can apply it on your finger and rub directly onto grey areas (sides, back, hairline), ensuring proper absorption. This makes the application more precise and effective compared to spray serums.

🔹Why choose REGENSIFY Hair Melanin Booster Lotion?

If you’re looking for a more nourishing, scalp-friendly solution that tackles both reversal and prevention, REGENSIFY Hair Melanin Booster Lotion provides a holistic approach that goes beyond just three patented actives.

✴️ Greyverse™ (2%), Darkenyl™ (1%), MelanoGray™ (2%): Triple-action melanin regeneration system.

✴️ He Shou Wu: Traditional Chinese herb known for anti-greying and hair longevity benefits.

✴️ Adenosine: boosts ATP, supports follicle health, as well as stronger, more active melanocytes producing more melanin

✴️ Coenzyme Q10: Anti-aging antioxidant, protects hair against oxidative damage. CoQ10 improves Mitochondrial function, allowing cells — including melanocytes — to stay energetic and functional for longer

✴️ SantEnergy™: Plant-based energizer that combats follicle fatigue and delays greying.

✴️ Biotin: Strengthens hair structure and resilience.

This formula combines patented anti-grey peptides with herbal, nutritional, and anti-aging support, creating a more holistic approach. You can read the previous blog titled Synergy: Adenosine and Coenzyme Q10: How They Help Prevent Grey Hair.

About the REGENSIFY Hair Melanin Booster Lotion

Powered with three patented innovative ingredients (2% Greyverse™, 1% Darkenyl™ and 2% MelanoGray™), the REGENSIFY Hair Melanin Booster Lotion is a revolutionary leave on lotion that can significantly help boost grey hair reversal and reduce the appearance of grey hair density without dyes or colorants. Greyverse™ contains an innovative α-MSH Biomimetic peptide that is able to stimulate the natural pigmentation process to recover a natural hair color. Both Darkenyl™ and MelanoGray™ contain Acetyl Tyrosine, which acts as Melanin Booster. The lotion is further enhanced with He Shou Wu, Adenosine, Coenzyme Q10, SantEnergy™ and Biotin to promote healthy hair growth. He Shou Wu is a natural Chinese herb remedy known for preventing premature hair greying. Coenzyme Q10 has anti-aging effects on hair and also protects the hair against hydrogen peroxide buildup (one of the root causes for hair greying) in your scalp. SantEnergy™ energises the hair follicle cells similar to that of caffeine and delays premature aging of hair follicle cells from environment oxidative damage. Adenosine and Coenzyme Q10 work synergistically by boosting and facilitating ATP production to stimulate the hair.

REVERSE GREY HAIR WITH REGENSIFY

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Disclaimer: All brand names and trademarks mentioned are the property of their respective owners. This article is intended for educational and informational purposes only, based on publicly available data and clinical studies.